PROCEDIMENTO PER ACCRESCERE IL FLUSSO PER ELETTROTRASPORTO DI POLIPEPTIDI

摘要

Methods for modifying polypeptide agents to enhance their transdermal electrotransport flux are provided. The polypeptide is modified by reducing the potential of the polypeptide for forming alpha-helical or beta-sheet segments. In particular, amino acid residues known to stabilize alpha-helical and beta-sheet segments can be replaced with destabilizing residues and known helix breakers. Modified molecules and compositions including the molecules are also provided.