PYRIDINECARBOXAMIDE DERIVATIVES

摘要

N-(12-Nitroxydodecyl)-6-(4-ethyl or isoproyl-1-piperazinyl)pyridine-3-carboxamide or physiologically acceptable salts thereof. These compounds are excellent in the effects of inhibiting cerebral edema, particularly ischemic cerebral edema, and inhibiting delayed neuron death (or inhibiting calcium inflow into neuros). They are useful as a cerebral edema inhibitor or a cerebrovascular disorder remedy, because cerebral edema is a pathological condition accompanying cerebrovascular disorder, particularly one observed in an acute stage. Because also they scarcely exhibit any behavior suppressing activity believed to be a side effect in the therapy of cerebrovascular disorder in an acute stage, they are especially excellent as a remedy therefor. In addition, they have the effects of protecting the brain (i.e., an antianoxic effect), increasing cerebral blood flow, and inhibiting lipid peroxidation, which further enhance the usefulness as a cerebrovascular disorder remedy.