APPARATUS FOR MULTI-WELL MICROSCALE SYNTHESIS

摘要

A multi-well synthesis and filtration apparatus (10) for performing multiple, simultaneous chemical reactions, workups and purifications on a micro scale. The apparatus (10) includes a deep-well synthesis block (12) having a plurality of wells (24) fitted with filter disks (48), an upper cover (14), a lower cover (16) and a pair of sheet gaskets (18 and 20). The sheet gaskets (18 and 20) are interposed between the upper and lower covers (14 and 16) to seal inlet portions (38) and outlet spouts (40) of the wells (24). Apertures (70) in the upper cover (14) provide that the sheet gasket (18) may be punctured for introduction of materials and/or maintenance of an inert atmosphere. The design is such that either the synthesis block (12) alone, or the block (12) as covered, is dimensionally of a size that provides for a footprint that is the same as a standard microplate.