发明名称 |
2R,4S,S,R- AND 2S,4R,S,R-HYDROXYITRACONAZOLE |
摘要 |
A method of preparation of optically pure isomers of hydroxyitraconazole, in particular the two cis dioxolane diastereomers of the sec-butyl (S,R)-isomer, and to phosphate and sulfate derivatives thereof is disclosed. Pharmaceutical compositions containing these compounds and to their use for the treatment of fungal infection are also disclosed.
|
申请公布号 |
CA2269616(A1) |
申请公布日期 |
1998.05.22 |
申请号 |
CA19972269616 |
申请日期 |
1997.11.12 |
申请人 |
SEPRACOR INC. |
发明人 |
TANOURY, GERALD J.;SENANAYAKE, CHRIS H.;HONG, YAPING;MCCULLOUGH, JOHN R.;KOCH, PATRICK |
分类号 |
C07D405/14;A61K31/496;A61P31/10;C07D249/12;C07D405/06;C07D521/00;(IPC1-7):C07D405/14;A61K31/495 |
主分类号 |
C07D405/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|