发明名称 |
P-SELECTIN ASSAYS AND METHODS OF USE THEREOF |
摘要 |
The present invention relates to a method of assessing the effect of "anti-platelet" agents, which affect the activation state of platelets, by monitoring levels of membrane bound and/or soluble P-selectin in a sample from an individual. In one embodiment, levels of P-selectin are monitored in a sample containing platelets (e.g., a blood sample, platelet rich plasma (PRP)) using an assay for membrane bound P-selectin. In another embodiment, levels of P-selectin are measured in a sample from which platelets have been removed (e.g., platelet poor plasma (PPP), serum), using an assay for soluble P-selectin. Another aspect of the invention includes measuring both membrane bound and soluble P-selectin to monitor platelet activation for patients who are receiving anti-platelet therapy. The method is useful for monitoring the effect of anti-platelet therapy on platelet activation state as reflected in membrane bound and/or soluble P-selectin levels. Anti-platelet therapy can be adjusted accordingly to maintain a desired level of platelet activation. In another aspect, the invention relates to a method of assessing the effect of a vascular intervention, and of coronary artery interventions in particular, on platelet activation state comprising determining the level of soluble P-selectin in a sample. Anti-platelet therapy can be initiated or adjusted in order to achieve a basal activation state, or other desired platelet activation state.
|
申请公布号 |
WO9821591(A1) |
申请公布日期 |
1998.05.22 |
申请号 |
WO1997US20571 |
申请日期 |
1997.11.13 |
申请人 |
CENTOCOR, INC.;DALESANDRO, MARGARET, R.;FREDERICK, BART;GUMBS, CINDY, I. |
发明人 |
DALESANDRO, MARGARET, R.;FREDERICK, BART;GUMBS, CINDY, I. |
分类号 |
G01N33/53;G01N33/15;G01N33/50;G01N33/68;(IPC1-7):G01N33/68;G01N33/60 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|