| 摘要 |
Heterocycles as inhibitors of leucocyte adhesion and as VLA4 antagonists Compounds of the formula I <IMG> in which B,D,E,R,W,Y,Z,b,c,d,e,f,g and have the meanings indicated in the claims, are inhibitors of the adhesion and migration of leucocytes and/or antago nists of the adhesion receptor VLA-4 which belongs to the group of integrins. The invention relates to the use of compounds of the formula I, and of pharmaceutica l preparations which contain such compounds, for the treatment and prophylaxis of diseases which are caused by an undesired extent of leucocyte adhesion and/or leucocyte migration or which are associated therewith or in which cell-cell or c ell-matrix interactions play a part which are based on interactions of VLA-4 recepto rs with their ligands, for example of inflammatory processes, rheumatoid arthritis or allergic disorders, and it also relates to the use of compounds of the formula I for the production of pharmaceuticals for use in such diseases. It further relates to no vel compounds of the formula I.
|
