| 摘要 |
<p>A new class of mammalian sprouty proteins is disclosed. The proteins are characterized by an amino acid sequence whose cysteine-rich region has at least 40 % sequence identity with SEQ ID NO:17 in the human sprouty 2 protein whose full length sequence is identified by SEQ ID NO:8. Also disclosed are (i) a pharmaceutical preparation containing a sprouty protein, (ii) a DNA sequence encoding the protein, (iii) vector and gene therapy compositions containing the DNA coding sequence, and (iv) methods of detecting a condition characterized by, or risk factor associated with, abnormal levels of active mammalian sprouty protein in a mammalian subject.</p> |
