FremgangsmÕte for fremstilling av (1S,4R)- eller (1R,4S)-4-(2-amino-6-klor-9H-pyrin-9-yl)

摘要

Racemic or optically active 1-amino-4-(hydroxymethyl)-2- cyclopentene derivatives are obtained by acylation of 1-amino-2-cyclopentene-4- carboxylic acid with an acid halide, followed by reduction of the carboxyl group. - A method for the production of racemic or optically active 4-(hydroxymethyl)-2-cyclopentene derivatives of formula (XIII) involves acylation of a cyclopentene-4-carboxylic acid derivative of formula (XIV) (as the racemate or an optically active isomer) with a carboxylic acid halide of formula R1-CO-X (XI), followed by reduction of the resulting acid derivative (XV): - R1 = 1-4C alkyl, 1-4C alkoxy, aryl or aryloxy; - X = halogen