| 发明名称 |
INTEGRIN ANTAGONISTS |
| 摘要 |
This invention relates to certain novel compounds and derivatives thereof, their synthesis, and their use as vitronectin receptor antagonists. The vitronectin receptor antagonist compounds of the present invention are alpha v beta 3 antagonists, alpha v beta 5 antagonists or dual alpha v beta 3/ alpha v beta 5 antagonists useful for inhibiting bone resorption, treating and preventing osteoporosis, and inhibiting restenosis, diabetic retinopathy, macular degeneration, angiogenesis, atherosclerosis, inflammation and tumor growth.
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| 申请公布号 |
WO9818460(A1) |
申请公布日期 |
1998.05.07 |
| 申请号 |
WO1997US19348 |
申请日期 |
1997.10.27 |
| 申请人 |
MERCK & CO., INC.;DUGGAN, MARK, E.;HARTMAN, GEORGE, D. |
发明人 |
DUGGAN, MARK, E.;HARTMAN, GEORGE, D. |
| 分类号 |
C07D235/04;A61K31/4184;A61K31/4375;A61K31/444;A61K31/4545;A61K45/06;A61P9/10;A61P9/14;A61P19/10;A61P35/00;A61P43/00;C07D213/73;C07D401/12;C07D401/14;C07D471/04;(IPC1-7):A61K31/18;A61K31/19;A61K31/44;A61K31/47;A61K31/195;A61K31/405;A61K31/415;A61K31/425;A61K31/435;A61K31/505;C07C63/00;C07C307/06;C07C307/08;C07C307/10;C07D209/40;C07D213/89;C07D217/08;C07D233/44;C07D239/08;C07D239/14;C07D239/42 |
主分类号 |
C07D235/04 |
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