发明名称 |
PROCESS FOR THE PREPARATION OF RADIOPHARMACEUTICALS |
摘要 |
Process for the preparation of radiohalogenated radiopharmaceuticals by an electrophillic substitution, preferably halogenodestannylation reactions, by the reaction of an organometallic substituted precursors, preferably a trialkyl tin substituted precursor, with a radioactive halogen, preferably a radioactive iodine, astatine or bromine composition, in the presence of a catalytically effective amount of an anion selected from the group consisting of bromide, chloride and nitrite anion in an acid medium with an oxidizing agent.
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申请公布号 |
WO9818499(A1) |
申请公布日期 |
1998.05.07 |
申请号 |
WO1997US19492 |
申请日期 |
1997.10.28 |
申请人 |
GUILFORD PHARMACEUTICALS INC. |
发明人 |
PIROTTE, ROBERT, JEAN, MARIE, DENIS;NOWOTNIK, DAVID, PETER;ABEYSEKERA, BRIAN, FREDRICK |
分类号 |
A61K51/00;A61K51/04;C07B59/00;C07D451/02;(IPC1-7):A61K51/04 |
主分类号 |
A61K51/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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