9-N-ETHENYL DERIVATIVES OF 9(S)-ERYTHROMYCYLAMINE

摘要

The invention relates to 9-N-ethenyl derivatives of 9(S)-erythromycylamine, new semisynthetic antibiotics of the macrolide class of the general formula (I) wherein R1 and R2 are the same or different and represent nitryl, a carboxyl group of the formula COOR3, wherein R3 represents a C1-C4-alkyl group, or a keto group of the formula COR4, wherein R4 represents a C1-C4-alkyl group, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for their preparation, to a process for the preparation of the pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in the treatment of bacterial infections.