| 摘要 |
<p>The present invention is directed to a compound of the following formula (I) inclusive of its salt <CHEM> Äwherein R<1> represents either carboxy which may be esterified or amidated carboxy which may be substituted; R<2> represents hydrogen or lower alkyl and may be linked to R<3> or R<4> to form a ring; R<3> and R<4> may be the same or different and each represents hydrogen, lower alkyl which may be substituted, or a sulfide group which may be substituted, and R<3> and R<4> may conjoinedly form a ring; R<5> represents a substituted phenyl group of formula (II) <CHEM> (wherein R<6> represents halogen or alkoxy) or a substi tuted sulfonyl group of formula (III) -SO2-R<7> (wherein R<7> represents either aryl which may be substituted by lower alkyl or amino which may be substituted); n is to 0 or 1Ü and to a method for producing the same compound. Having cysteine protease-inhibitory activity, the compound of the invention is of value as a prophylactic or therapeutic agent for a variety of cysteine protease-associated diseases, for example ischemic diseases, inflammatory diseases, myodystrophy, immune diseases, essential hypertension, Alzheimer's disease, subarachnoid hemorrhage, and osteoporosis.</p> |
