Novel polythiophene compounds useful as anti-tumor agents are described. Preferred compounds of the formula: <IMAGE> wherein n is 0-2 and R2 and R3 are optionally substituted 2-thienyl or 3-thienyl have been found to exhibit selective cytotoxic activity against transformed human cells. Pharmaceutical compositions containing the described polythiophene compounds are expected to exhibit good chemotherapeutic activity against slow growing tumors based on tumor cell line assays. A method for treating patients having tumors utilizing the disclosed polythiophene compounds is also described.
申请公布号
US5741811(A)
申请公布日期
1998.04.21
申请号
US19960712854
申请日期
1996.09.12
申请人
PURDUE RESEARCH FOUNDATION;INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE
发明人
CHANG, CHING TE;CHANG, CHING-JER;LEE, CHEN-TAO;LIN, FEN-LAN;TSAI, JIH-DAR;ASHENDEL, CURTIS L.;CHAN, THOMAS C. K.;GEAHLEN, ROBERT L.;WATERS, DAVID J.