CARBOHYDRATE-SPECIFIC CYTOLYTIC T CELLS

摘要

An immunogenic composition containing a carbohydrate moiety linked to an internal amino acid of the polypeptide, wherein the polypeptide binds with high affinity to a polypeptide binding groove of a MHC class I molecule with the carbohydrate moiety extending beyond the polypeptide binding groove of the MHC molecule to stimulate the T cell to specifically lyse a target cell comprising the carbohydrate moiety its surface, and a method for stimulating a CD8<+> T cell to lyse target cells in a carbohydrate-specific manner.