发明名称 |
INHIBITION OF BCL-2 PROTEIN EXPRESSION BY LIPOSOMAL ANTISENSE OLIGODEOXYNUCLEOTIDES |
摘要 |
The present invention provides novel compositions and methods for use in the treatment of Bcl-2-associated diseases like cancer, specifically, in the treatment of follicular lymphoma (FL). The compositions contain antisense oligonucleotides that hybridize to Bcl-2 nucleic acids, the gene products of which are known to interact with the tumorigenic protein Bcl-2. Used alone, or in conjunction with other antisense oligonucleotides, these compositions inhibit the proliferation of FL cancer cells.
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申请公布号 |
CA2266584(A1) |
申请公布日期 |
1998.04.09 |
申请号 |
CA19972266584 |
申请日期 |
1997.10.03 |
申请人 |
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM |
发明人 |
TORMO, MAR;LOPEZ-BERESTEIN, GABRIEL;MCDONNELL, TIMOTHY J.;TARI, ANA M. |
分类号 |
C12N15/09;A61K9/127;A61K31/7088;A61K38/00;A61K48/00;A61P35/00;A61P43/00;C12N15/113;(IPC1-7):A61K48/00;A61K31/70;A61K31/708;C12N15/85 |
主分类号 |
C12N15/09 |
代理机构 |
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地址 |
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