| 摘要 |
<p>A bioreactor apparatus (200) according to the present invention consists of two chambers, a feed and waste chamber (216) and cell chamber (215) separated by a selectively permeable ultrafiltration membrane (210). Within the cell chamber (215), a biocompatible three dimensional matrix entraps the animal cells. Due to the presence of this biocompatible matrix, the cell chamber (215) generally has a gel phase, i.e., the biocompatible matrix and cells, and a liquid phase containing a concentrated solution of the cell product to be harvested. Thus, the bioreactor of this invention uses only two chambers to achieve three distinct zones within the apparatus.</p> |
