Encapsulation of antineoplastic agents in liposomes
摘要
Methods for encapsulating ionizable antineoplastic agents in liposomes using transmembrane potentials are provided. Trapping efficiencies approaching 100% and rapid loading are readily achieved. Dehydration protocols which allow liposomes to be conveniently used in the administration of antineoplastic agents in a clinical setting are also provided. In accordance with other aspects of the invention, transmembrane potentials are used to reduce the rate of release of ionizable drugs from liposomes.
申请公布号
US5736155(A)
申请公布日期
1998.04.07
申请号
US19950461212
申请日期
1995.06.05
申请人
THE LIPOSOME COMPANY, INC.
发明人
BALLY, MARCEL B.;CULLIS, PIETER R.;HOPE, MICHAEL J.;MADDEN, THOMAS D.;MAYER, LAWRENCE D.