| 摘要 |
A method is described for inhibiting the growth of mammalian cells, in particular, for inhibiting the growth of cancer cells, by the use of certain N-acetonylarylamide derivatives having the structural formula (see fig. I) wherein: A is selected from the group consisting of phenyl, pyridyl, furyl, thienyl, isoxazolyl, oxazolyl, pyrrolyl, isothiazolyl, thiazolyl, pyrazolyl, imidazolyl, pyrimidinyl, quinolyl, isoquinolyl, pyridazinyl, pyrazinyl, benzothienyl, indolyl, benzofuranyl, benzyl, (C3-C7) cycloalkyl, (C1-C6) alkyl, halo (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C1-C6) alkoxyl, and halo (C1-C6) alkoxyl, A is selected from phenyl, pyridyl, furyl, thienyl, isoxazolyl, oxazolyl, pyrrolyl, isothiazolyl, thiazolyl pyrazolyl, imidazolyl, pyrimidinyl, quinolyl, isoquinolyl, naphthyl, pyridazinyl, pyrazinyl, benzothienyl, indolyl, benzofuranyl, or benzyl, any of which may be substituted with up to four substituents, each independently selected from halo, cyano (C1-C6) alkyl, halo (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynlyl, (C2-C6) alkoxyl, halo (C1-C6) alkoxyl, nitro, -NR6R7, -CR8=NOR9, NHCOOR10, -CONR11R12, and -COOR13; or from (C3-C7) cycloalkyl, (C1-C6) alkyl, (C1-C6) alkylthio, halo (C1-C6) alkyl, (C2-C6 ) alkenyl, (C2-C6) alkynyl, (C1-C6) alkoxyl, or halo (C1-C6) alkoxyl; R1 and R2 are each independently selected from H, (C1-C6) alkyl, halo (C1-C6) alkyl, (C2-C6) alkenyl, and (C2-C6) alkynyl, provided that at least one of R1 and R2 is not H; R6 and R7 are each independently selected from H, (C1-C6) alkyl, and (C1-C6) alkylcarbonyl; R8 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, and (C2-C6) alkynyl; R9 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, and (C1-C4) alkylcarbonyl; R10 is selected from H, (C1-C6) alkyl, C2-C6) alkenyl, and (C2-C6) alkynyl; R11 and R12 are each independently selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, and (C2-C6) alkynyl; R13 is selected from H, (C1-C6) alkyl, (C2-C6) alkenyl, and (C2-C6) alkynyl; and X, Y and Z are each independently selected from H, halo, cyano, thiocyano, isothiocyano and (C1-C6) alkylsulfonyloxy, provided that at least one of X, Y and Z is halo, cyano, thiocyano, isothiocyano or (C1-C6) alkylsulfonyloxy.
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