P53-DEPENDENT SECRETION OF GROWTH INHIBITORY FACTORS

摘要

The present invention relates to a method for preparing a preparation of p53-dependent growth inhibitory factors for use in a pharmaceutical composition. Cultured human cells, capable of expressing p53 tumor suppressor protein, are induced to express and secrete p53-dependent growth inhibitory factors into the culture medium, where the growth inhibitory factors are recovered to prepare a preparation for use in a pharmaceutical composition. This pharmaceutical composition is then used in a method for reducing unwanted or abnormal cell proliferation by administering an effective amount to a subject in need thereof.