MULTIMERIC, RECOMBINANT UREASE VACCINE

摘要

Methods and compositions are provided for preventing and/or treating Helicobacter (e.g., H. pylori) infection. The compositions of the invention, which are used in the methods of the invention (which include mucosal administration of the compositions), include compositions containing multimeric complexes of recombinant, enzymatically inactive Helicobacter urease in a pharmaceutically acceptable carrier or diluent; and compositions containing (a) a Helicobacter antigen, and (b) an antibiotic, an antisecretory agent, a bismuth salt, or a combination thereof.