| 摘要 |
An erythromycin A derivative represented by the formula (I): <IMAGE> (I) [wherein R1 is a group represented by the formula: -OCOCH2Y (wherein Y is a pyridyl group, a quinolyl group, a p-nitrophenyl group or a group represented by the formula: -NR4R5 (wherein R4 and R5 may be the same or different, and are each a hydrogen atom, a methyl group, a pyridylmethyl, a quinolylmethyl group or a benzyloxycarbonyl group)) or a cladinosyloxy group, R2 is a hydrogen atom, or R1 and R2 together form an oxo group, R3 is a hydrogen atom, an acetyl group, an ethylsuccinyl group or a nicotinoyl group] or a pharmaceutically acceptable salt thereof has a strong antibacterial activity against not only Gram-positive bacteria but also some Gram-negative bacteria, in particular, Haemophilus influenzae which is a serious factor of infectious diseases in the respiratory organs. |
