<p>An engineered pumping segment for facilitating efficient and accurate peristaltic pumping of fluids, providing regulation of fluid flow and providing an effective interface for sensing fluid line pressure in a peristaltic pump system. The engineered pumping segment includes an elastomeric membrane sandwiched between a rigid base and a rigid cover and a slider adapted to slidably mount about the base and cover. The membrane and base define a channel for fluid flow and the membrane, base and cover cooperate to facilitate peristaltic pumping of fluids through the engineered pumping segment and to provide a pressure sensing interface, and in combination with the slider, cooperate to regulate fluid flow.</p>
