Pharmaceutical compounds.

摘要

The invention provides pharmaceutical compounds of the formula: in which A --- B is CH2-CH2 or CH=CH; X is a pyridine or benzene ring; when X is pyridine n is 0; when X is benzene n is 0, 1 or 2 and when A --- B is CH2-CH2, R<1> is attached at any of the positions 7 to 10, and when A --- B is CH=CH, R<1> is attached at any of the positions 5 to 10; each R<1> is halo, carboxy, trifluoromethyl, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, hydroxy-C1-4 alkyl, hydroxy-C1-4 alkoxy, nitrogen-containing heterocyclyl, nitro, trifluoromethoxy, -COOR<5> where R<5> is an ester group, -COR<6>, -CONR<6>R<7> or -NR<6>R<7> where R<6> and R<7> are each hydrogen or C1-4 alkyl; R<2> is phenyl, naphthyl or heteroaryl selected from thienyl, pyridyl, benzothienyl, quinolinyl, benzofuranyl or benzimidazolyl, said phenyl, naphthyl and heteroaryl groups being optionally substituted, or R<2> is furanyl optionally substituted with C1-4 alkyl; R<3> is nitrile, carboxy, -COOR<8> where R<8> is an ester group, -CONR<9>R<1><0> where R<9> and R<1><0> are each hydrogen or C1-4 alkyl, or -SO2R<1><1> where R<1><1> is C1-4 alkyl, optionally substituted phenyl or optionally substituted phenyl-C1-4 alkyl; and R<4> is 1-pyrrolyl, 1-imidazolyl or 1-pyrazolyl, said 1-pyrrolyl, 1-imidazolyl and 1-pyrazolyl being optionally substituted by one or two C1-4 alkyl, carboxyl, hydroxy-C1-4 alkyl or -CHO groups, or 1-(1,2,4-triazolyl), 1-(1,3,4-triazolyl) or 2-(1,2,3-triazolyl), said triazolyl groups being optionally substituted by a C1-4 alkyl or C1-4 perfluoroalkyl group, or 1-tetrazolyl optionally substituted by C1-4 alkyl; and salts thereof.o