PHENYL SUBSTITUTED CYCLOALKYL HYDROXYUREA DERIVATIVES WHICH INHIBIT LIPOXYGENASE.

摘要

Certain novel phenylsubstituted cycloalkylurea compounds having the ability to inhibit the enzyme 5-lipoxygenase and having formula (I); wherein A is C1-C4 alkylene or C2-C6 alkenylene; each B is independently halogen, C1-C4 alkyl, C2-C8 alkoxyalkyl or halosubstituted C1-C4 alkyl; X is methylene or ethylene; M is hydrogen or a pharmaceutically acceptable cation; A r is phenyl or mono-, di- or tri-substituted phenyl wherein the substituents are each independently selected from halogen, C1-C4 alkyl, C1-C4 alkoxy, halosubstituted C1-C4 alkyl, (C1-C4 alkyl)phenoxy, (C1-C4 alkoxy)phenoxy, halosubstituted phenoxy, halosubstituted (C1-C4 alkyl)phenoxy, phenylthio, (C1-C4 alkyl)phenylthio, (C1-C4 alkoxy)phenylthio, halosubstituted phenylthio and halosubstituted (C1-C4 alkyl)phenylthio; A, B and Ar may be attached at any available position on the ring; m is 0 or 1; and n is 0, 1 or 2. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergic conditions and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.