Process for preparing N-tert-butyl-2-pyrazinecarboxamide and N-tert-butyl-2-piperazinecarboxamide

摘要

PCT No. PCT/JP94/01972 Sec. 371 Date Jul. 20, 1995 Sec. 102(e) Date Jul. 20, 1995 PCT Filed Nov. 21, 1994 PCT Pub. No. WO95/14675 PCT Pub. Date Jun. 1, 1995A process for preparing a N-tert-butyl-2-pyrazinecarboxamide having the formula (2): <IMAGE> (2) which comprises reacting a cyanopyrazine having the formula (1): <IMAGE> (1) with tert-butyl alcohol in the presence of sulfuric acid and a process for preparing a N-tert-butyl-2-piperazine-carboxamide having the formula (3): <IMAGE> (3) which comprises hydrogenating of said N-tert-butyl-2-pyrazinecarboxamide having the formula (2) in the presence of Raney nickel or Raney cobalt.