| 摘要 |
PCT No. PCT/US95/02077 Sec. 371 Date Sep. 24, 1996 Sec. 102(e) Date Sep. 24, 1996 PCT Filed Feb. 16, 1995 PCT Pub. No. WO95/22361 PCT Pub. Date Aug. 24, 1995A process is provided for non-glutaraldehyde fixation of an organ or prosthesis to be implanted in a mammal. The process produces stable fixation of the tissue by forming amide linkages within and between the molecules of the tissue and employs a coupling agent, such as EDC, in combination with a coupling enhancer, such as Sulfo-NHS; diamine and/or dicarboxyl cross-linking agents are optionally included. In addition to fixing the tissue, the process prevents or retards calcification and results in a nontoxic product that does not cause inflammation.
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