发明名称 |
Method of causing selective immunosuppression using hl-60-related lectins |
摘要 |
The invention provides methods of treating a neoplastic disease characterized by proliferation of lymphocytes by administering pharmaceutical compositions comprising a soluble lectin having a molecular weight of about 14 kilodaltons. In addition, methods of treating a lectin-producing tumor by administering an effective amount of an antibody that specifically binds the lectin, lectin antagonists, inhibitory saccharides, or glycosylation inhibitors in order to prevent lectin-induced apoptosis of tumor-infiltrating T cells. |
申请公布号 |
AU4091397(A) |
申请公布日期 |
1998.03.19 |
申请号 |
AU19970040913 |
申请日期 |
1997.08.26 |
申请人 |
INCYTE PHARMACEUTICALS, INC.;REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE |
发明人 |
LINDA G. BAUM;NANCY L. PERILLO;JEFFREY J. SEILHAMER |
分类号 |
A61K38/00;A61K38/17;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|