NOVEL PHYSIOLOGICALLY ACTIVE NA23063 ANALOGUES, PROCESS FOR PRODUCING THE SAME AND USE OF THE SAME

摘要

Novel physiologically active NA23063 analogues and pharmacologically acceptable salts thereof. Microorganisms belonging to the genus Streptomyces and capable of producing physiologically active substances NA23063A, B1, B2, C and D were incubated in a medium and the physiologically active substances NA23063A, B1, B2, C and D thus accumulated in the culture were collected. These compounds were further converted into derivatives thereof. For example, the structure of NA23063D is given below. <CHEM> Because of having the effect of inhibiting phosphodiesterases, the compounds are useful as the active ingredient of, for example, an antiasthmatic agent, a bronchodilator, a remedy for bronchitis, an antiallergic agent, an anti-inflammatory agent, an antirheumatic agent, a hypotensive drug, a remedy for angina pectoris, a remedy for arrhythmia, a cerebral vasodilator, a blood coagulation inhibiting agent or an antidepressant agent.