摘要 |
PCT No. PCT/GB94/01859 Sec. 371 Date May 2, 1996 Sec. 102(e) Date May 2, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/06040 PCT Pub. Date Mar. 2, 1995A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: <IMAGE> I wherein: (a) R4 is an alkyl, cycloalkyl or aryl group. (b) R10 is chosen from halo, OH, CH3, OCH3, NR11R12, NO2, NHCHO, CO2H and CN, and R11 and R12 are independently selected from H and alkyl (C1-C5) or together NR11R12 form a cyclic structure II, <IMAGE> II wherein a is 1-6; and (c) R2 is an aromatic 5- or 6-membered, substituted or unsubstituted heterocycle containing at least two heteroatoms of which at least one is nitrogen. These compounds are gastrin and/or CCK-B receptor antagonists.
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申请人 |
FERRING-RESEARCH LIMITED;YAMANOUCHI PHARMACEUTICAL CO. LTD. |
发明人 |
SEMPLE, GRAEME;RYDER, HAMISH;SZELKE, MICHAEL;SATOH, MASATO;OHTA, MITSUAKI;MIYATA, KEIJI;NISHIDA, AKITO;ISHII, MASATO |