The present invention relates to an intestinal peptide that is located in mammalian distal ileum. The peptide, designated "enteric neural peptide" or "ENP", corresponds to the N-terminal, 13 amino acid fragment of somatostatin-28. ENP is localized in cells that do not express S-28 and do not contain the C-terminal S-14 fragment of prosomatostatin. ENP increases in the circulation within 30 minutes of intake of mixed food, wherein the predominant nutrient signal is fat. Antibodies that bind ENP are also disclosed.
申请公布号
WO9809991(A2)
申请公布日期
1998.03.12
申请号
WO1997US15578
申请日期
1997.09.04
申请人
ZYMOGENETICS, INC.;UNIVERSITY OF WASHINGTON
发明人
ENSINCK, JOHN, W.;VOGEL, ROBIN, E.;LASCHANSKY, ELLEN, C.;FRANCIS, BRUCE, H.;BASKIN, DENIS, G.;D'ALESSIO, DAVID, A.;HOFFMAN, ROSS, C.