The invention relates to methods and compositions for inhibition of viral replication in animal cells. In particular, inhibition of viral replication in a target cell is achieved by introducing into the cell (1) a protein which can be incorporated along with wild type nucleocapsid subunits into a viral nucleocapsid assembling within the cell, and thereby renders the nucleocapsid deficient in encapsidating viral nucleic acid; or (2) a recombinant nucleic acid construct that directs overexpression of the protein.
申请公布号
WO9809649(A1)
申请公布日期
1998.03.12
申请号
WO1997US15500
申请日期
1997.09.03
申请人
THE GENERAL HOSPITAL CORPORATION;WANDS, JACK, R.;SCAGLIONI, PIER, PAOLO;MELEGARI, MARGHERITA