| 摘要 |
A pharmaceutical composition and a method of forming said composition for the sustained release of biologically active agent. The pharmaceutical composition of the invention comprises (a) a sustained release delivery device consisting essentially of (i) a drug delivery device having a biologically active agent disposed within said device and characterized by a plurality of interior spaces, and (ii) a hydrophobic material wherein said material is contained within a substantial number of interior spaces of the drug delivery device as to have a beneficial effect and (b) a pharmaceutical carrier. Alternatively, the pharmaceutical composition of the invention is in the substantial absence of a pharmaceutical carrier. The method of the invention includes imbibing the interior spaces of the drug delivery device with a hydrophobic material and removing the hydrophobic material from the exterior surface, thereby obtaining a pharmaceutical composition with a significantly reduced initial burst. |
