发明名称 |
CYCLIC ETHER COMPOUNDS AS SODIUM CHANNEL MODULATORS |
摘要 |
A compound of formula (I) wherein R1 and R2 each represents hydrogen, lower alkyl which may be substituted or acyl; R3, R4 and R5 each represents lower alkyl which may be substituted or lower alkoxy which may be substituted or R4 and R5 taken together represent a 5- or 6-membered carbocyclic group; R6 represents lower alkyl; Ar represents an aromatic group which may be substituted; ring A represents a 5- to 8-membered nitrogen-containing heterocyclic ring which may be substituted; X represents lowe alkylene which may be substituted; Y represents carbon or nitrogen; Za represents CH2, COCH2, OCH2, SCH2, NHCH2, etc.; Zb represents a bond or a divalent aliphatic hydrocarbon group which may be substituted and may contain O, N or S; and m represents an integer of 1 to 3, or a salt thereof is useful for a pharmaceutical composition for modulating sodium channel.
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申请公布号 |
CA2264231(A1) |
申请公布日期 |
1998.03.05 |
申请号 |
CA19972264231 |
申请日期 |
1997.08.28 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
HASHIMOTO, TADATOSHI;FUKATSU, KOHJI;OHKAWA, SHIGENORI |
分类号 |
C07D307/81;C07D405/06;C07D407/12;(IPC1-7):C07D405/06;A61K31/335;A61K31/495 |
主分类号 |
C07D307/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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