| 摘要 |
<p>An improved coating and spacer material for a medical device having a blood or tissue-contacting surface comprising a polyalkyleneimine layer which is cross-linked with a cross-linking agent which is at least difunctional in polymerizable vinyl groups which have adjacent strong electron-withdrawing groups and a biomolecule covalently bonded to the cross-linked polyalkyleneimine layer. For example, polyethyleneimine cross-linked with divinyl sulfone could be used. The resulting cross-linked spacer layer has improved uniformity and stability without materially limiting the covalent attachment of a biomolecule such as heparin.</p> |
