The present invention relates to a novel soluble IL-1 receptor accessory molecule (IL-1R AcM) protein which is a member of the Ig superfamily. In particular, isolated nucleic acid molecules are provided encoding the human IL-1R AcM protein. IL-1R AcM polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. Screening methods are further provided for identifying agonist and antagonists of IL-1 signal transduction. The invention further relates to methods for treating physiologic and pathologic disease conditions with IL-1R AcM antagonists.
申请公布号
WO9808969(A1)
申请公布日期
1998.03.05
申请号
WO1996US13954
申请日期
1996.08.26
申请人
HUMAN GENOME SCIENCES, INC.;BEDNARIK, DANIEL, P.;OLSEN, HENRIK, S.;ROSEN, CRAIG, A.
发明人
BEDNARIK, DANIEL, P.;OLSEN, HENRIK, S.;ROSEN, CRAIG, A.