发明名称 |
Method of treating an IL-6 related disease with interleukin-6 receptor antagonists |
摘要 |
This invention provides a class of interleukin-6 (IL-6) muteins which act as IL-6 receptor antagonists, thereby inhibiting the normal function of naturally-occurring IL-6. These IL-6 receptor antagonism are preferably IL-6 molecules containing one or more mutations in the Site II region comprising amino acids 154-163. This invention also provides pharmaceutical compositions comprising IL-6 receptor antagonists with a pharmaceutically acceptable carrier. This invention further provides methods for treating IL-6 related diseases such as sepsis and multiple myeloma, the methods comprising administering to a patient an IL-6 receptor antagonist.
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申请公布号 |
US5723120(A) |
申请公布日期 |
1998.03.03 |
申请号 |
US19950476651 |
申请日期 |
1995.06.07 |
申请人 |
CHIRON CORPORATION;CENTRAL LABORATORY OF THE NETHERLANDS RED CROSS BLOOD TRANSFUSION SERVICE |
发明人 |
BRAKENHOFF, JUST P. J.;AARDEN, LUCIEN A. |
分类号 |
C12N15/09;A61K38/00;A61P29/00;A61P31/04;A61P35/00;A61P35/02;A61P37/00;C07K14/54;C12N1/21;C12N15/24;C12P21/02;C12R1/19;(IPC1-7):A61K38/19 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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