| 摘要 |
<p>N-(Pyrido-thienyl or pyrido-furanyl)-oxazolidinone derivatives (I) as pure stereoisomers or stereoisomer mixtures and their salts are new: A = O; S; or SO2; D, E, G, L = at least 1 N atom or -CR<2>; R<1> = N3; OH; OR<10>; -OSO2R<11>; or -NR<12>R<13>; R<2> = H; CN; COOH; alkyl, acyl or alkoxy with up to 7C; halo; -NR<3>R<4>; -CO-NR<5>R<6>; -NH-CO-R<8>; or S(O)aR<9>; R<3>-R<8> = H; Ph; or 1-6C alkyl; a = 0-2; R<9> = Ph or 1-4C alkyl; R<10> = acyl with up to 8C or a OH protecting group; R<11> = 1-4C alkyl; or Ph optionally substituted by 1-4C alkyl; R<12>, R<13> = H; 3-6C cycloalkyl; Ph; 1-8C alkyl; 1-8C alkoxy; or a NH2 protecting group; or one of R<12> and R<13> can be -COR<14>, -CSR<14>', P(O)(OR<15>)(OR<16>) or -SO2-R<17>; R<14>, R<14>' = H; 3-6C cycloalkyl; CF3; 1-8C alkoxy; Ph; Ph-CH2O; 1-8C alkyl optionally substituted by halo, CN or CF3; thioalkyl or acyl with up to 6C; or -NR<18>R<19>; R<15>, R<16> = H or 1-4C alkyl; R<17> = 1-4C alkyl or Ph; R<18>, R<19> = H; Ph; 1-6C alkyl; or 5-membered heteroaryl containing 1-3 S, N and/or O atoms.</p> |
