| 发明名称 |
MDR reversal agents |
| 摘要 |
<p>Compounds of the general formula: <CHEM> wherein R1, R2, R3, R4 and R5 are herein described, A is a straight or branched (C2-C12)alkyl or a phenyl moiety and B is a moiety of the formula: <CHEM> The compounds are effective in potentiating the activity of chemotherapeutic anti-cancer agents by increasing the sensitivity of multi-drug resistant cells to such chemotherapeutic agents.</p> |
| 申请公布号 |
SI634401(T1) |
申请公布日期 |
1998.02.28 |
| 申请号 |
SI19940030091T |
申请日期 |
1994.06.29 |
| 申请人 |
AMERICAN CYANAMID COMPANY |
发明人 |
POWELL DENNIS;PAUL ROLF;HALLETT WILLIAM A.;BERGER DAN M.;DUTIA MINU D. |
| 分类号 |
A61K31/40;A61K31/403;A61K31/4035;A61K31/47;A61K31/472;A61K45/00;A61P35/00;A61P43/00;C07C323/07;C07C323/16;C07C323/56;C07C323/60;C07D209/44;C07D209/48;C07D215/20;C07D217/02;C07D217/04;C07D217/06;C07D217/20;C07D217/24;C07D401/12;C07D405/06;C07D491/04;C07D491/056;C07D521/00;C07F7/10;C07F7/18;(IPC1-7):C07D217/24 |
主分类号 |
A61K31/40 |
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