TRANSISTOR-BASED APPARATUS AND METHOD FOR MOLECULAR DETECTION AND FIELD ENHANCEMENT

摘要

Binding of a molecule (24) to a molecular receptor (22) is sensed using a transistor (10) having a gate (14) located at a binding site. The channel (20) conductance of the transistor (10) is modified by a charge associated with the molecule (24) when the molecule (24) binds with the molecular receptor (22). A modified electrical characteristic of the transistor (10) which results is sensed to sense the binding event. Electric field enhancement is provided by applying a voltage to the gate (14). A second sensing transistor can be coupled to the sensing transistor to form a differential pair. The differential pair allows for enhancing and sensing of differential binding events.