摘要 |
<p>A benzothiazole derivative or a pharmacologically acceptable salt thereof which is useful as a preventive or therapeutic agent for diseases on which functions of suppressing leukotrienes and thromboxanes production are effective. A benzothiazole derivative represented by the following general formula (I): <CHEM> wherein R<1> and R<3> are either same or different and each represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a group represented by the formula: <CHEM> (wherein p is an integer of from 1 to 4), or a group represented by the formula: <CHEM> (wherein R<7> represents a lower alkyl group); R<4> represents a hydrogen atom, a lower alkyl group, a phenyl group, a group represented by the formula: <CHEM> (wherein q is an integer of from 1 to 4), or a group represented by the formula: <CHEM> (wherein R<7> represents a lower alkyl group); or R<3> and R<4> may form a benzene ring together with the carbon atoms to which they are bound; R<2> represents a hydrogen atom or a protective group of a hydroxyl group; and R<5> and R<6> are either same or different and each represents a hydrogen atom, a lower alkyl group, a group represented by the formula: <CHEM> (wherein r is an integer of from 1 to 4), or an acyl group; or a pharmacologically acceptable salt thereof.</p> |
申请人 |
EISAI CO., LTD., TOKIO/TOKYO, JP |
发明人 |
OKAMOTO, YASUSHI, TSUKUBA-SHI, IBARAKI, JP;TAGAMI, KATSUYA, TSUKUBA-SHI, IBARAKI, JP;HIBI, SHIGEKI, TSUKUBA-SHI, IBARAKI, JP;NUMATA, HIROTOSHI, TSUKUBA-SHI, IBARAKI, JP;KOBAYASHI, NAOKI, TSUKUBA-SHI, IBARAKI, JP;SHINODA, MASANOBU, TSUKUBA-SHI, IBARAKI, JP;KAWAHARA, TETSUYA, TSUKUBA-SHI, IBARAKI, JP;MURAKAMI, MANABU, TSUKUBA-SHI, IBARAKI, JP;OKETANI, KIYOSHI, TSUKUBA-SHI, IBARAKI, JP;INOUE, TAKASHI, TSUKUBA-SHI, IBARAKI, JP;YAMANAKA, TAKASHI, TSUKUBA-SHI, IBARAKI, JP;YAMATSU, ISAO, USHIKU-SHI, IBARAKI, JP |