| 摘要 |
<p>Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof wherein (a) represents an aromatic or alicyclic ring; R1 and R2 are the same or different and represent hydrogen, C1-C6 alkyl, halogen, hydroxy, amino, cyano, nitro, trifluoromethyl, trifluoromethoxy, C1-C6 alkoxy, -O2CR', -NHCOR', -COR', -SOmR', where R' is C1-C6 alkyl and wherein m is 0, 1 or 2; or R1 and R2 independently represent -CONR'R'', or -NR'R'' where R' and R'' independently represent hydrogen or C1-C6 alkyl; R3 is hydrogen, C1-C6 alkyl, or -COR''' where R''' is C1-C6 alkyl; R4 is hydrogen or C1-C6 alkyl; and R represents an azacycloalkylalkyl group, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention are useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.</p> |
