| 摘要 |
<p>This invention provides a compound of the formula: <CHEM> and its pharmaceutically acceptable salts, wherein Ar<1> is selected from groups of the following formulae: <CHEM> wherein, R<1> and R<2> are independently hydrogen or C1-C6 alkyl; W is (CH2)n wherein n is from 1 to 3, or -CH=CH-; X is C1-C6 alkoxy or halo C1-C6 alkoxy; and Ar<2> is phenyl optionally substituted by halogen atom. These compounds are useful in the treatment of a gastrointestinal disorder, a central nervous system (CNS) disorder, an inflammatory disease, emesis, urinary incontinence, pain, migraine, sunburn, angiogenesis, diseases, disorders and adverse conditions caused by Helicobacter pylori, or the like in a mammalian subject, especially humans.</p> |
