| 摘要 |
The invention relates to new and known tricyclic dione derivatives of the general formula <CHEM> wherein W represents hydrogen or lower alkyl; X represents lower alkyl; Y represents an oxygen atom or NR<1>; R<1> represents hydrogen, lower alkyl, lower alkoxycarbonyl or lower alkoxycarbonyl-lower alkyl; Z represents aryl or heteroaryl optionally substituted by one or more halo, cyano, nitro, lower alkyl, halo-lower alkyl, lower alkoxy, halo-lower alkoxy, COR<2>, OCOR<2>, CO2R<2>, OR<2>, S(O)nR<2>, NR<2>R<3>, N(R<4>)COR<5>, Ar, Ar-lower alkyl, Het or Het-lower alkyl substituents and/or on adjacent carbon atoms by lower alkylenedioxy; R<2>, R<3>, R<4> and R<5> each individually represent hydrogen, lower alkyl, Ar, Ar-lower alkyl, Het or Het-lower alkyl substituents; or R<2> and R<3> together represent the group -CH=CH-CH=CH- or -CH=N-CH=CH-; Ar represents aryl optionally substituted by one or more halo, lower alkyl, lower alkoxy or nitro substituents; Het represents heteroaryl optionally substituted by one or more halo, lower alkyl, lower alkoxy or nitro substituents; and n stands for 0, 1 or 2 and to their salts which are inhibitors of herpes simplex virus thymidine kinase in the treatment and prophylaxis of infections caused by herpes simplex virus. |
