NON-IONIC POLYOL CONTRAST MEDIA FROM IONIC CONTRAST MEDIA

摘要

Novel non-ionic contrast media are efficiently prepared from generally available ionic contrast media or non-iodinated precursors. Particularly, polyhydroxyhalo-hydrocarbons are employed with a triiodo-substituted acylamido benzoic acids in aqueous weakly basic media to selectively substitute the amido nitrogen, followed by activation of the carboxyl group for amide formation.