YEAST HAVING MUTATIONAL TYPE TRANSCRIPTIONAL CONTROL FACTOR

摘要

PROBLEM TO BE SOLVED: To obtain glutathione with good productivity without being suppressed by a culture medium component such as methionine by culturing a yeast having a mutational type MET4 gene in which a specific amino acid residue is mutated into another amino acid residue as a mutational type transcriptional control factor. SOLUTION: This yeast has a mutational type MET4 gene in which at least either one of an amino acid at the 215th position of MET4 and an amino acid at the 156th position thereof is mutated into another amino acid residue, preferably the amino acid residue at the 215th position of the MET4 is mutated into Pro or the amino acid residue at the 156th position thereof is mutated into Ser as a mutational type transcriptional control factor. Furthermore, the yeast having the mutational type MET4 gene is cultured to afford glutathione.