2- and 2,5-substituted phenylketoenols.

摘要

Halophenyl-heterocyclic ketone compounds of formula (I) are new. X = halo, alkyl, alkenyl, alkynyl, alkoxy, benzyloxy, haloalkyl, haloalkoxy, CN or NO2; Z = H, amino, halo, alkyl, alkoxy, haloalkyl, haloalkoxy, OH, CN, NO2, OAr' or SAr'; Ar' = phenyl, 5-6 membered heteroaryl or phenylalkyl (all optionally substituted); Ar = a group of formula (a)-(c); Y = NH, O or S; A = alkyl, alkenyl, alkoxyalkyl, polyalkoxyalkyl or alkylthioalkyl (all optionally substituted), cycloalkyl or heterocyclyl (both optionally unsaturated and optionally substituted); or aryl, arylalkyl or heteroaryl (all optionally substituted by halo, alkyl, haloalkyl, alkoxy, haloalkoxy, CN or NO2); B = alkyl or alkoxyalkyl; or CAB = saturated or unsaturated, optionally substituted carbocycle or heterocycle; D = H, alkyl, alkenyl, alkynyl, alkoxyalkyl, polyalkoxyalkyl or alkylthioalkyl, saturated or unsaturated cycloalkyl, saturated or unsaturated heterocyclyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl (all optionally substituted); or A+D complete optionally substituted carbocycle or heterocycle; G = H, C(O)R1, C(=L)MR2, SO2R3, P(=L)R4R5, E or C(=L)-NR6R7; E = a metal ion equivalent or an ammonium ion; L, M = O or S; R1 = alkyl, alkenyl, alkoxyalkyl, alkylthioalkyl or polyalkoxyalkyl (all optionally substituted by halo); cycloalkyl or heterocyclyl (both optionally substituted by halo, alkyl or alkoxy); or phenyl, phenylalkyl, heteroaryl, phenoxyalkyl or heteroaryloxyalkyl (all optionally substituted); R2 = alkyl, alkenyl, alkoxyalkyl or polyalkoxyalkyl (all optionally substituted by halo); or cycloalkyl, phenyl or benzyl (all optionally substituted); R3-R5 = alkyl, alkoxy, mono- or di-aminoalkyl, alkylthio, alkenylthio or cycloalkylthio (all optionally substituted by halo); or Ar", CH2Ar", OAr" or SAr"; Ar" = optionally substituted phenyl; R6, R7 = H, Ar" or CH2Ar"; or alkyl, alkenyl, alkoxy, cycloalkyl or alkoxyalkyl (all optionally substituted by halo); or NR6R7 = a cyclic group which is optionally substituted and optionally contains O or S.