A vaccine is described which comprises an assembly-deficient herpesvirus. The mutant herpesvirus is capable of infecting and undergoing DNA replication in the cells of a susceptible mammal, but is defective in capsid assembly and formation of mature virion particles. The assembly-deficient herpesvirus is avirulent and capable of generating a protective immune response in a vaccinated mammal.
申请公布号
WO9804286(A2)
申请公布日期
1998.02.05
申请号
WO1997US14192
申请日期
1997.07.25
申请人
G.D. SEARLE & CO.;HIPPENMEYER, PAUL, J.;RANKIN, ANNE, M.;LUCKOW, VERNE, A.
发明人
HIPPENMEYER, PAUL, J.;RANKIN, ANNE, M.;LUCKOW, VERNE, A.