发明名称 |
THE USE OF PROTEINASE INHIBITORS FOR PREVENTION OR REDUCTION OF BONE RESORPTION |
摘要 |
Bone metabolic disease is treated by inhibition of the production or action of membrane-type matrix metalloproteinase (MT-MMP) or the matrix metalloproteinase 12 (MMP-12) involved in the resorptive activity of osteoclasts. Inhibitors for MT-MMP and MMP-12 and membrane-associated metalloproteinase activity include peptides and analogues of peptides generated using a PEGA bead library, antisense nucleic acid agents and antibodies. The proteinases MT1-MMP and MMP-12 are found to be expressed in osteoclasts and may be selectively inhibited.
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申请公布号 |
CA2261567(A1) |
申请公布日期 |
1998.02.05 |
申请号 |
CA19972261567 |
申请日期 |
1997.07.29 |
申请人 |
CENTER FOR CLINICAL & BASIC RESEARCH |
发明人 |
MELDAL, MORTEN;DELAISSE, JEAN-MARIE;FOGED, NIELS TAEKKER |
分类号 |
A61K45/00;A61K39/395;A61K48/00;A61P19/08;A61P19/10;C07K1/04;C07K14/81;C07K16/40;(IPC1-7):A61K39/395;A61K38/03;A61K38/08;A61K38/55;A61K31/70 |
主分类号 |
A61K45/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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