| 摘要 |
Selected sulfonylalkanoylamino hydroxyethylamine sulphonamide compounds of general formula (I) or pharmaceutical acceptable salts thereof, medicament precursors or esters thereof, wherein in the formula (I) the substituents R1, R2, R3, R4 and R5 have their meaning specified in description and patent claims, whilst n and t are individually 0, 1 or 2. These compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease. The present invention relates to such retroviral protease inhibitors and, more particularly, relates to selected novel compounds, composition and method for inhibiting retroviral proteases, such as human immunodeficiency virus (HIV) protease, prophylactically preventing retroviral infection or the spread of a retrovirus, and treatment of a retroviral infection.
|
