发明名称 |
DNA VACCINES AGAINST ROTAVIRUS INFECTIONS |
摘要 |
<p>This invention relates to methods of eliciting an immune response and/or protective immunity in a vertebrate by introducing into the vertebrate a DNA vaccine which consists essentially of DNA encoding an antigen or antigens, e.g., capsid proteins or polypeptides, of rotavirus. The uptake of the DNA vaccine by a host vertebrate results in the expression of the capsid protein, thereby eliciting humoral or cell-mediated immune responses, or both, which can provide protection against infection and/or prevent clinically significant rotavirus-caused disease. In addition, the invention demonstrates that an internal vital antigen provides protective immunity in a host. The host can be any vertebrate, including birds, piglets, and humans.</p> |
申请公布号 |
EP0821583(A1) |
申请公布日期 |
1998.02.04 |
申请号 |
EP19950927480 |
申请日期 |
1995.07.26 |
申请人 |
UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER |
发明人 |
HERMANN, JOHN, E.;ROBINSON, HARRIET, L.;FYNAN, ELLEN, F. |
分类号 |
A61K9/16;A61K38/00;A61K39/00;A61K39/145;A61K39/15;A61K39/21;A61K48/00;C07K14/11;C07K14/14;C07K14/155;C07K14/16;C12N15/46;C12N15/867;C12N15/87;(IPC1-7):A61K31/00 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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